About Glyburide/ Glibenclamide 5mg + Metformin HCL 500mg
Buy Glyburide/ Glibenclamide 5mg + Metformin HCL 500mg
Drug Class: What is Gabitril? an why is it prescribed?
Glucovance Mechanism: How does Gabitril work?
Glucovance Dosage: How should you take Gabitril
Possible food and drug interactions when taking Gabitril
Special information on Gabitril
Gabitril side effects
|Drug Class: What is Gabitril? an why is it prescribed?|
|Glucovance is a combination of Glyburide/Glibenclamide and Metformin. Glyburide/Glibenclamide is in a class of drugs called sulfonylureas. Glyburide/Glibenclamide is used to help control blood sugar levels by stimulating the pancreas to release more insulin into the blood. Metformin is also used to regulate blood sugar levels. Metformin works in three ways: first, Metformin reduces the amount of glucose (sugar) produced by your liver; second, Metformin reduces the amount of glucose absorbed from food through your stomach; and third, Metformin makes the insulin that your body produces work better to reduce the amount of glucose already in your blood. Glucovance is used with diet and exercise to treat non-insulin-dependent (type 2) diabetes. Glucovance may also be used for purposes other than those listed in this medication guide.|
|Glucovance Mechanism: How does Gabitril work?|
|Glucovance combines metformin hydrochloride and glyburide/glibenclamide, two antihyperglycemic agents with complementary mechanisms of action, to improve glycemic control in patients with type 2 diabetes. Glyburide/Glibenclamide appears to lower blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. The mechanism by which Glyburide/Glibenclamide lowers blood glucose during long-term administration has not been clearly established. With chronic administration in patients with type 2 diabetes, the blood glucose lowering effects persists despite a gradual decline in the insulin secretory response to the drug. Extrapancreatic effects may be involved in the mechanism of action of oral sulfonylurea hypoglycemic drugs. Metformin hydrochloride is an antihyperglycemic agent that improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. Metformin hydrochloride decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.|
|Glucovance Dosage: How should you take Gabitril|
|Take Glucovance tablets by mouth with meals. Swallow the Glucovance tablets with a drink of water. Take your doses at the same time each day; do not take more often than directed. Adults Your doctor will start therapy at a low dose and increase it until your blood sugar levels are under control. For patients not previously treated with diabetes medications The recommended starting dose is 2.5 mg of glyburide/glibenclamide with 500 mg of metformin once daily with meals. The dosage can be increased every two weeks until blood sugar levels are controlled. The maximum recommended daily dose of Glucovance for previously untreated patients is 10 milligrams of glyburide/glibenclamide with 1,000 milligrams of metformin. For patients previously treated with glyburide (or a similar drug) or metformin: The recommended starting dose of Glucovance is either 2.5 or 5 milligrams of glyburide/glibenclamide with 500 milligrams of metformin twice daily with meals. The maximum recommended daily dosage of Glucovance for previously treated patients is 10 milligrams of glyburide/glibenclamide with 1,000 milligrams of metformin. Children Glucovance is not for use in children. Older Adults Since kidney function declines with age, it should be closely monitored in people taking Glucovance after age 65. Older patients are usually not prescribed the maximum recommended dose of Glucovance. If you miss a Glucovance dose If you miss a dose of Glucovance, take Glucovance as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses of Glucovance. Glucovance Overdose Glucovance overdose may lead to serious consequences. Seek medical emergency immediately. Symptoms of Glucovance overdose may include • hunger, • nausea, • anxiety, • cold sweats, • weakness, • drowsiness, • unconsciousness, • coma, • trigger lactic acidosis Glucovance Storage instructions Keep Glucovance out of the reach of children in a container that small children cannot open. Store Glucovance at room temperature between 15 and 25 degrees C (59 and 77 degrees F). Keep container tightly closed and protect from light. Throw away any unused amount of Glucovance after the expiration date. Preparations: Tablet- Glyburide/ Glibenclamide 2.5mg + Metformin HCL 500mg Glyburide/ Glibenclamide 5mg + Metformin HCL 500mg|
|Possible food and drug interactions when taking Gabitril|
The following drugs should not be taken with Glucovance
Many medications may cause changes (increase or decrease) in blood sugar, these include:
Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way Glucovance works. Check with your health care professional before stopping or starting any of your medicines.
|Special information on Gabitril|
|Most Important Fact about Glucovance Very rarely, Glucovance has been known to cause a dangerous condition called lactic acidosis, a buildup of lactic acid in the blood. Lactic acidosis is a medical emergency that requires immediate treatment in the hospital. Notify your doctor without delay if you experience any of the following symptoms: • a slow or irregular heartbeat; • a cold, dizzy, or light-headed feeling; • a weak, tired, or uncomfortable feeling; • stomach discomfort; • trouble breathing; • unusual muscle pain Glucovance precautions if you are pregnant or breastfeeding Glucovance is not recommended during pregnancy. To control blood sugar during this crucial period, most doctors prefer insulin instead of Glucovance. If you are pregnant or plan to become pregnant, inform your doctor immediately. You\'ll also need to avoid Glucovance while breastfeeding. If blood sugar becomes a problem, your doctor can prescribe insulin. Special warnings about Glucovance Avoid excessive alcohol intake while taking Glucovance. Heavy drinking increases the danger of lactic acidosis and can also trigger an attack of low blood sugar (hypoglycemia). Missed meals, malnutrition, general debility, liver or kidney problems, other medications, and over-exertion also increase the risk of hypoglycemia. Symptoms of a mild case include cold sweats, dizziness, shakiness, and hunger. Severe hypoglycemia can lead to seizures and coma. If you notice any of the warning signs, check with your doctor immediately. Lactic acidosis also becomes more likely when you become dehydrated. If you experience severe vomiting, diarrhea, fever, or if your fluid intake is significantly reduced, tell your doctor. Glucovance occasionally causes a mild deficiency of vitamin B12. Your doctor will check annually and may prescribe a supplement if necessary. Some experts suspect that the glyburide/glibenclamide component of Glucovance may lead to more heart problems than treatment with diet alone. In a long-term trial of a similar drug, researchers noted an increase in heart-related deaths (though the overall mortality rate remained unchanged). If you have a heart condition, you may want to discuss this potential risk with your doctor.|
|Gabitril side effects|
|Why Glucovance should not be prescribed? Glucovance should not be used incase of severe liver disease. Glucovance should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using Glucovance and inform your doctor or pharmacist immediately. Possible Glucovance Side effects More common side effects of Glucovance may include: • cold sweats, • diarrhea, • dizziness, • headache, • hunger, • nausea, • shakiness, • stomach pain, • upper respiratory infections, • vomiting Less common or rare side effects of Glucovance may include: • breathing difficulties or shortness of breath • dark yellow or brown urine • dizziness • fever, chills, or frequent sore throats • muscle pain • passing out or fainting • severe vomiting or diarrhea • skin rash • slow or irregular heartbeat • unusual weakness, fatigue or discomfort • unusual stomach pain or discomfort • yellowing of the eyes or skin|
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