Drug Class: What is Lioresal and why is it prescribed?
Lioresal Mechanism: How does Lioresal work?
Lioresal Dosage: How should you take Lioresal
Possible food and drug interactions when taking Lioresal
Special information on Lioresal
Lioresal side effects
|Drug Class: What is Lioresal and why is it prescribed?|
|Generic Lioresal (baclofen) is a muscle relaxant. It is used to treat spasticity of the skeletal muscles and improve mobility in patients with multiple sclerosis by decreasing muscular spasm and rigidity. Generic Lioresal also improves bowel and bladder function in some patients.|
|Lioresal Mechanism: How does Lioresal work?|
Chemically, Generic Lioresal (baclofen) is related to gamma-aminobutyric acid (GABA) which is a naturally-occurring neurotransmitter in the brain, that is, a chemical that nerves use to communicate with one another. GABA released by some nerves causes the electrical activity of other nerves to decrease. It is believed that baclofen, by acting like GABA, blocks the nerves within the reticular formation of the brain that control the muscles.
Generic Lioresal was approved by the FDA in November 1977.
|Lioresal Dosage: How should you take Lioresal|
|The determination of baclofen\'s optimal dosage requires individual titration. Start therapy at a low dosage and increase gradually until optimum effect is achieved (usually between 40 to 80 mg daily).
The following dosage titration schedule is suggested: 5 mg 3 times daily for 3 days; 10 mg 3 times daily for 3 days; 15 mg 3 times daily for 3 days; 20 mg 3 times daily for 3 days.
Thereafter, additional increases may be necessary but the total daily dose should not exceed a maximum of 80 mg daily (20 mg 4 times daily).
Utilize the lowest dose compatible with an optimal response. If benefits are not evident after a reasonable trial period, withdraw patients slowly from the drug.
If you miss a Generic Lioresal dose
Generic Lioresal Overdose
Symptoms of Generic Lioresal overdose may include:
Generic Lioresal Preparations
|Possible food and drug interactions when taking Lioresal|
|When Generic Lioresal is taken together with alcohol or sedative medicines, increased sedation may occur.
When Generic Lioresal is taken together with tricyclic antidepressantss severe muscular weakness may occur.
Generic Lioresal may increase the blood pressure-lowering efects of anti-hypertensive medicines.
Medicines which reduce renal function may reduce Generic Lioresal excretion and increase the likelihood of side effects.
When Generic Lioresal is taken together with levodopa plus carbidopa (for Parkinson\'s disease) mental confusion, hallucinations and agitation may occur.
If Generic Lioresal is taken together with lithium, severe hyperkinetic symptoms may be aggravated.
|Special information on Lioresal|
|Most important fact about Generic Lioresal
Generic Lioresal should be used with caution in Decreased kidney function, Decreased liver function, Disease affecting the airways or lungs (respiratory disease), Disorders of the muscle (sphincter) which controls urine outflow from the bladder, Elderly people, Epilepsy, History of stroke, people who have previously had peptic ulcer disease, Psychiatric disorders.
Special precautions if you are pregnant or breastfeeding
Special Warnings about Generic Lioresal
Why Generic Lioresal should not be prescribed?
|Lioresal side effects|
|Most common side effects of Generic Lioresal may include:
Drowsiness, weakness, dizziness or lightheadedness, headache, nausea, vomiting, low blood pressure, constipation, tiredness, confusion, inability to sleep, and increased urinary frequency.
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