Drug Class: What is Zestril and why is it prescribed?
Drug Mechanism: How does Zestril work?
Dosage: How should you take Zestril
Possible food and drug interactions when taking Zestril
Special information on Zestril
Zestril side effects
|Drug Class: What is Zestril and why is it prescribed?|
Generic Zestril is in a class of drugs called angiotensin-converting-enzyme (ACE) inhibitors.
Generic Zestril is used in the treatment of high blood pressure. Generic Zestril is used to lower blood pressure, to treat congestive heart failure, and to improve the survival rate after a heart attack.
Generic Zestril is effective when used alone or when combined with other high blood pressure medications. Generic Zestril may also be used with other medications in the treatment of heart failure, and may be given within 24 hours of a heart attack to improve chances of survival.
Generic Zestril is indicated as adjunctive therapy in the management of heart failure in patients who are not responding adequately to diuretics and digitalis.
Generic Zestril works by reducing production of a substance that increases salt and water retention in your body. Generic Zestril decreases certain chemicals that tighten the blood vessels, so blood flows more smoothly and the heart can pump blood more efficiently.
|Drug Mechanism: How does Zestril work?|
Generic Zestril contains the active ingredient lisinopril, which is a type of medicine called an ACE inhibitor.
ACE inhibitors work by blocking the action of a compound in the body called angiotensin converting enzyme (ACE). Angiotensin is a chemical that is made by the body continuously. It narrows blood vessels and thereby maintains (elevates) blood pressure. When the enzyme is blocked by Generic Zestril, angiotensin cannot be converted into its active form. As a result, blood pressure falls.
Normally ACE produces another compound called angiotensin II, as part of the bodys natural control of blood pressure. Angiotensin II has two actions. Firstly, it causes blood vessels to constrict and narrow, and secondly, it reduces the production of urine by the kidneys. Both these actions increase the pressure within the blood vessels.
As Generic Zestril blocks the action of ACE, it reduces the production of angiotensin II. This means that the blood vessels are allowed to relax to widen and more urine is produced by the kidneys. The overall effect of this is a drop in blood pressure.
The reduced pressure within the blood vessels means that the heart doesnot have to work as hard to pump the blood around the body. This is why Generic Zestril can be used to improve the symptoms of heart failure, where the heart is not pumping as efficiently, and to improve survival following a heart attack.
The effects of Generic Zestril in hypertension and heart failure appear to result primarily from suppression of the renin-angiotensin-aldosterone system. Inhibition of ACE results in decreased plasma angiotensin II, which leads to decreased vasopressor activity and to decreased aldosterone secretion.
|Dosage: How should you take Zestril|
Generic Zestril can be taken with or without food. Take it exactly as prescribed. Stopping Generic Zestril suddenly could cause your blood pressure to rise.
If you miss a Generic Zestril dose
High Blood Pressure
Diuretic use should, if possible, be stopped before using Generic Zestril. If not, your physician may give an initial dose of 5 milligrams under supervision before any further medication is prescribed.
People with kidney disorders must be carefully monitored, and dosages will be adjusted to the individuals needs, depending on kidney function.
Pediatric Hypertensive Patients less than or 6 years of age
Generic Zestril Overdose
A severe drop in blood pressure is the primary sign of a Generic Zestril overdose.
Symptoms of a Generic Zestril overdose include extreme dizziness, weakness, fainting, and fatigue.
Generic Zestril Storage instructions
Generic Zestril Preparations
|Possible food and drug interactions when taking Zestril|
If Generic Zestril is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining lisinopril with any of the following:
Tell your doctor if you use salt substitutes that contain potassium.
Avoid drinking alcohol while taking Generic Zestril.
|Special information on Zestril|
Most important fact about Generic Zestril
If you have high blood pressure, you must take Generic Zestril regularly for it to be effective. Since blood pressure declines gradually, it may be several weeks before you get the full benefit of Generic Zestril; and you must continue taking it even if you are feeling well. Generic Zestril does not cure high blood pressure; it merely keeps it under control.
Special precautions if you are pregnant or breastfeeding
It is not known whether Generic Zestril passes into breast milk, and its effects on a nursing baby are not known. Do not take Generic Zestril without first talking to your doctor if you are breast-feeding a baby.
Special warnings about Generic Zestril
If you are being given bee or wasp venom to guard against future reactions, you may have a severe reaction to Generic Zestril.
Alcohol may enhance the blood pressure lowering effect of Generic Zestril, which may result in dizziness or fainting.
If you have congestive heart failure or other heart problems, a kidney disorder, or a connective tissue disease such as lupus, you should use Generic Zestril with caution. Your doctor may perform periodic blood tests while you are taking Generic Zestril
If you are taking Generic Zestril, a complete assessment of your kidney function should be done and kidney function should continue to be monitored. Generic Zestril is used with great caution after a heart attack if the patient also has kidney problems.
Generic Zestril also should be used with caution if you are on dialysis. There have been reports of extreme allergic reactions during dialysis in people taking Generic Zestril.
If you are taking high doses of a diuretic (water pill) and Generic Zestril, you may develop excessively low blood pressure. This problem is also more likely if you are being treated for heart failure.
Generic Zestril may cause some people to become dizzy, light-headed, or faint, especially if they have heart failure or are taking a water pill at the same time. Some people may experience dizziness caused by low blood pressure in the first few days of taking Generic Zestril. This can be relieved by lying down until the symptoms pass. If affected you should avoid performing potentially hazardous tasks such as driving or operating machinary.
If you develop chest pain, sore throat, fever, and chills, contact your doctor for medical attention. It could indicate a more serious condition.
If your skin and the whites of your eyes turn yellow, stop taking Generic Zestril and contact your doctor.
Avoid salt substitutes that contain potassium. Limit your consumption of potassium-rich foods such as bananas, prunes, raisins, orange juice, and whole and skim milk. Ask your doctor for advice on how much of these foods to consume.
Generic Zestril should be used with caution in patients with decreased kidney function, diabetes, disease of the blood vessels in and around the brain (cerebrovascular disease), diseases affecting connective tissue, eg scleroderma, systemic lupus erythematosus, rheumatoid arthritis (collagen vascular diseases), heart disease caused by inadequate blood flow to the heart (ischaemic heart disease), low blood pressure (hypotension), narrowing of blood vessels in the extremities (peripheral vascular disease), narrowing of the artery which supplies blood to the kidneys (renal artery stenosis), people aged over 70 years, people receiving therapy to remove certain types of fat from the blood using a machine (LDL apheresis), people taking blood pressure lowering medicines, people undergoing therapy to decrease allergy to bee or wasp stings (desensitisation), people with low fluid volume or salt levels in the body, eg due to diuretic therapy, low-sodium diet, diarrhoea or vomiting, severe heart failure.
Generic Zestril should not to be used in people with any condition in which there is obstruction to the pumping of blood out of the heart (outflow tract obstruction), enlargement of a chamber of the heart (right ventricle) due to high blood pressure in the pulmonary artery (cor pulmonale), heart disease characterised by thickening of the internal heart muscle and a blockage inside the heart (hypertrophic obstructive cardiomyopathy), hereditary angioedema (angioneurotic oedema), history of swelling of the lips, face or tongue (angioedema) caused by Generic Zestril, history of swelling of the lips, face or tongue with no known cause (idiopathic angioedema), kidney failure requiring a certain type of haemodialysis (high-flux membrane), narrowing of the main artery of the body (aortic stenosis), pregnancy, excessive sweating, dehydration, severe diarrhea, or vomiting could cause you to lose too much water and cause your blood pressure to drop dangerously.
|Zestril side effects|
If you are sensitive to or have ever had an allergic reaction to Generic Zestril or other ACE inhibitors such as Capoten, you should not take Generic Zestril. You should also avoid Generic Zestril if you suffered angioedema (swelling of the face, lips, tongue, throat, arms, or legs) during previous treatment with an ACE inhibitor, or have a tendency to develop the condition for any other reason. Make sure your doctor is aware of any drug reactions you have experienced.
Possible Generic Zestril side effects
More common side effects of Generic Zestril may include:
Less common or rare side effects of Generic Zestril may include:
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