Drug Class: What is Lioresal and why is it prescribed?
Drug Mechanism: How does it work?
Dosage: How should you take Lioresal?
Possible food and drug interactions when taking Lioresal
Special information on Lioresal
Lioresal side effects
|Drug Class: What is Lioresal and why is it prescribed?|
|Lioresal (Baclofen) is a muscle relaxant. Lioresal is used to treat spasticity of the skeletal muscles and improve mobility in patients with multiple sclerosis by decreasing muscular spasm and rigidity. Lioresal also improves bowel and bladder function in some patients.|
|Drug Mechanism: How does it work?|
| Chemically, Lioresal(baclofen) is related to gamma-aminobutyric acid
(GABA) which is a naturally-occurring neurotransmitter in the brain, that is,
a chemical that nerves use to communicate with one another. GABA released
by some nerves causes the electrical activity of other nerves to decrease.
It is believed that Lioresal (baclofen), by acting like GABA, blocks the nerves within the reticular formation of the brain that control the muscles. Lioresal (Baclofen) was approved
|Dosage: How should you take Lioresal?|
| In adults, 5 mg of Lioresal usually is given three times per day, with
the dose gradually increased to 40-80 mg/day given in divided Lioresal doses.
Children ages 2 years and above are started at an initial Lioresal dose of 10-15 mg/kg/day orally in 3 divided doses with the dose gradually increased to a dose of 40-60 mg/day. Lioresal (Baclofen) may be administered with food or milk to minimize abdominal pain.
Lioresal Preparations: Tablets 10mg, 25mg.
|Possible food and drug interactions when taking Lioresal|
| Use of Lioresal (baclofen) with other central nervous system (CNS) depressants--e.g.
ethanol, opiate agonists such as Percocet, Dilaudid-antipsychotics--e.g. Thorazine,
Stelazine, Haldol-anxiolytics--e.g. Valium, Ativan, Ambien--certain antihistamines--e.g.
Benadryl, Vistaril, Tavist)--can increase CNS depression.
In addition to the risk of central nervous system (CNS) depression, the use of Lioresal (baclofen) and tricyclic antidepressants--e.g. Elavil, Sinequan--may cause muscle weakness. Use of baclofen and monoamine oxidase
|Special information on Lioresal|
Lioresal special information:
|Lioresal side effects|
|The most common side effects of Lioresal (baclofen) therapy include drowsiness, weakness, dizziness or lightheadedness, headache, nausea, vomiting, low blood pressure, constipation, tiredness, confusion, inability to sleep, and increased urinary frequency.|
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